Amy Schumer Reveals Sexual Side Effect of Alleged 'Botched Colonoscopy'

Amy Schumer will always keep it real - no matter what.

"I feel happier than I've ever been before," Schumer, 44, said during a "Not Skinny But Not Fat" podcast event with Dear Media. "I actually had, kind of, a botched colonoscopy, so I'm not feeling very sexual."

A colonoscopy is an outpatient procedure in which a doctor examines the large intestine through a microscopic camera to screen for colorectal cancer. While the comedian did not further elaborate on the alleged colonoscopy mishap, she has previously been candid about her health challenges.

"I feel reborn," Schumer wrote in a 2024 issue of the "News Not Noise" newsletter, confirming that she had been diagnosed with exogenous Cushing syndrome. "There are a few types of Cushing. Some that can be fatal, require brain surgery or removal of adrenal glands."

Cushing syndrome is often brought on by high-dose steroid injections, and is characterized by a round, red and full face, as well thin skin and weight gain. Per the Mayo Clinic, Cushing occurs when the body has an excess of the hormone cortisol.

Schumer was diagnosed after receiving an onslaught of online comments about her supposedly puffy face.

"I was getting these steroid injections, and so it gave me this thing called Cushing syndrome; which I wouldn't have known if the internet hadn't come for me so hard," she said on the "Call Her Daddy" podcast in 2025. "I learned that I had something called ‘moon face,' and I'm starring in a movie [Netflix's Kinda Pregnant] and there's a camera in my face, and I'm like, ‘Oh my God.' I was feeling really down on myself before I started filming this movie."

As Schumer started to feel better thanks to her friends' support, the swelling began to dissolve on its own. The actress has also been on a weight loss journey, entrusting GLP-1 medications to slim down.

"Three years ago, I tried Wegovy. I was puking, I couldn't handle it. I don't know if they've changed the formula, whatever," she said in a March 2025 social media video. "I went on this Telehealth meeting with Midi Health, and it was cheap. I wanted to try it myself ‘cause I wanted to recommend it to my friends who are nurses and teachers. They put me on estrogen and progesterone because I realized I was in perimenopause and my symptoms from being perimenopause have disappeared."

She continued, "My hair is fuller, my skin is better, I have more energy, I want to get down more, if you know what I mean. I'm talking about sex. So that's been great and Mounjaro's been great."

Schumer is currently separated from estranged husband Chris Fischer, with whom she shares son Gene.

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This story was originally published May 17, 2026 at 3:00 PM.